@article{PAR00012932,
  title = {{A}n {O}utbreak of {K}ingella kingae {I}nfections {A}ssociated with {H}and, {F}oot and {M}outh {D}isease/{H}erpangina {V}irus {O}utbreak in {M}arseille, {F}rance, 2013},
  author = {{E}l {H}oumami, {N}. and {M}inodier, {P}. and {D}ubourg, {G}. and {M}artin-{L}aval, {A}. and {L}afont, {E}. and {J}ouve, {J}. {L}. and {C}harrel, {R}. and {R}aoult, {D}idier and {F}ournier, {P}. {E}.},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {O}utbreaks of invasive {K}ingella kingae infections recently emerged as a new public health concern in daycare centers in {E}urope, {USA} and {I}srael. {D}espite this, no trigger factor has been yet identified, preventing the setting up of rational measures of control and prevention. {W}e report an outbreak of {K}. kingae infections associated with hand, foot and mouth disease/herpangina outbreak, and we define the research and policy priorities. {M}ethods: {F}rom {A}pril 22 to {M}ay 07, 2013, 5 toddlers presented successive osteo-articular infections in a daycare center in {M}arseille, {F}rance. {R}ealtime polymerase chain reaction targeting the cpn60 gene of {K}. kingae was used to investigate suspected cases and the prevalence of oropharyngeal {K}. kingae carriage of their close contacts. {R}esults: {T}he attack rate of the {K}. kingae infections outbreak was 23.7% (5/21) with no fatality. {P}ositive real-time polymerase chain reaction targeting the cpn60 gene of {K}. kingae confirmed the diagnosis in 3 cases and revealed a rate of {K}. kingae oropharynx carriage in the index classroom of 94.4% (17/18) among daycare attendees not given antibiotic during the previous month, and of 76.9% (10/13) among staff in close contact. {T}he eradication rate of {K}. kingae was 21.4% (3/14) among classmates after oral administration of rifampicin, and eradication occurred spontaneously in 83.3% (5/6) of the staff. {C}linical and epidemiological features of the herpangina outbreak were consistent with that of an emerging {E}uropean {C}oxsackievirus-{A}6 outbreak. {C}onclusions: {H}and, foot and mouth disease/herpangina virus outbreak enables triggering a {K}. kingae infections outbreak. {O}ur findings offer support for new guidelines of {K}. kingae infections outbreaks management and emphasize the need for further research.},
  keywords = {{K}ingella kingae ; outbreak ; hand foot and mouth disease ; herpangina ; {FRANCE}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {34},
  numero = {3},
  pages = {246--250},
  ISSN = {0891-3668},
  year = {2015},
  DOI = {10.1097/inf.0000000000000572},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012932},
}