@article{PAR00012827,
  title = {{I}ncreasing burden of urinary tract infections due to intrinsic colistin-resistant bacteria in hospitals in {M}arseille, {F}rance},
  author = {{A}bat, {C}. and {D}esboves, {G}. and {O}laitan, {A}. {O}. and {C}haudet, {H}. and {R}oattino, {N}. and {F}ournier, {P}. {E}. and {C}olson, {P}. and {R}aoult, {D}idier and {R}olain, {J}. {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he emergence of multidrug-resistant ({MDR}) {G}ram-negative bacteria has become a major public health problem, eliciting renewed interest in colistin, an old antibiotic that is now routinely used to treat {MDR} bacterial infections. {H}ere we investigated whether colistin use has affected the prevalence of infections due to intrinsic colistin-resistant bacteria ({CRB}) in university hospitals in {M}arseille ({F}rance) over a 5-year period. {A}ll data from patients infected by intrinsic {CRB} were compiled from {J}anuary 2009 to {D}ecember 2013. {E}scherichia coli infections were used for comparison. {C}olistin consumption data were also collected from pharmacy records from 2008 to 2013. {A} total of 4847 intrinsic {CRB} infections, including 3150 {P}roteus spp., 847 {M}organella spp., 704 {S}erratia spp. and 146 {P}rovidencia spp., were collected between 2009 and 2013. {D}uring this period, the annual incidence rate of hospital-acquired {CRB} infections increased from 220 per 1000 patients to 230 per 1000 patients and that of community-acquired {CRB} infections increased from 100 per 1000 patients to 140 per 1000 patients. {I}n parallel, colistin consumption increased 2.2-fold from 2008 to 2013, mainly because of an increase in the use of colistin aerosol forms (from 50 unitary doses to 2926 unitary doses; {P} < 10(-5)) that was significantly correlated with an increase in the number of patients positive for {CRB} admitted to {ICU}s and units of long-term care between 2009 and 2013 (r = 0.91; {P} = 0.03). {T}he global rise in infections due to intrinsic {CRB} is worrying and surveillance is warranted to better characterise this intriguing epidemiological change.},
  keywords = {{C}olistin resistance ; {M}arseille ; {P}roteus spp. ; {H}ospital-acquired ; infections ; {C}ommunity acquired infections ; {FRANCE}},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {A}ntimicrobial {A}gents},
  volume = {45},
  numero = {2},
  pages = {144--150},
  ISSN = {0924-8579},
  year = {2015},
  DOI = {10.1016/j.ijantimicag.2014.10.010},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012827},
}