Emonet S., Wuillemin T., Harbarth S., Wassilew N., Cikirikcioglu M., Schrenzel J., Lagier J. C., Raoult Didier, van Delden C. (2015). Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline. International Journal of Infectious Diseases, 30, p. 17-19. ISSN 1201-9712.
Titre du document
Relapse of Tropheryma whipplei endocarditis treated by trimethoprim/sulfamethoxazole, cured by hydroxychloroquine plus doxycycline
Emonet S., Wuillemin T., Harbarth S., Wassilew N., Cikirikcioglu M., Schrenzel J., Lagier J. C., Raoult Didier, van Delden C.
Source
International Journal of Infectious Diseases, 2015,
30, p. 17-19 ISSN 1201-9712
The best treatment for Tropheryma whipplei infections is controversial. We report a patient who suffered from T. whipplei aortic native valve endocarditis that relapsed despite surgery and four weeks of intravenous ceftriaxone followed by several months of oral trimethoprim/sulfamethoxazole. Cure was achieved after replacement of the prosthesis with a homograft and 18 months of oral doxycycline-hydroxychloroquine. We discuss the need for a change in treatment guidelines for T. whipplei infections.
