%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A D'Amato, F.
%A Rouli, L.
%A Edouard, S.
%A Tyczka, J.
%A Million, M.
%A Robert, C.
%A Nguyen, T. T.
%A Raoult, Didier
%T The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clonese
%D 2014
%L PAR00012718
%G ENG
%J Comparative Immunology Microbiology and Infectious Diseases
%@ 0147-9571
%K Coxiella burnetii ; Z3055 ; Epidemic ; Netherlands
%K PAYS BAS
%M ISI:000347133900002
%N 5-6
%P 281-288
%R 10.1016/j.cimid.2014.08.003
%U https://www.documentation.ird.fr/hor/PAR00012718
%V 37
%W Horizon (IRD)
%X Coxiella burnetii is a pathogen causing Q fever. The aim of our work was to study Z3055, a strain that is genotypically related to the strain causing the Netherlands outbreak. We compared Z3055 to 5 other completed genomes available in GenBank. We calculated the blast score ratio (BSR) to analyze genetic differences among the strains. The ratio core genome/pangenome was 98% likely other bacteria with closed pangenomes. Differences between Z3055 and the reference NMI consisted only of point mutations and insertion/deletion (INDELs). Non-synonymous mutations significantly increased in genes coding for membrane proteins (16/156 vs 103/1757, bilateral Chi(2) test, p <0.05), ankyrin repeat domains containing proteins (2/9 vs 117/1904, bilateral Chi(2) test, p <0.05), transcription factors (7/53 vs 112/1860, bilateral Chi(2) test, p <0.05) and translation proteins (15/144 vs 109/1655, bilateral Chi(2) test, p < 0.05). The evolution of this strain may have been driven by mutations in critical genes.
%$ 052