@article{PAR00012718,
  title = {{T}he genome of {C}oxiella burnetii {Z}3055, a clone linked to the {N}etherlands {Q} fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clonese},
  author = {{D}'{A}mato, {F}. and {R}ouli, {L}. and {E}douard, {S}. and {T}yczka, {J}. and {M}illion, {M}. and {R}obert, {C}. and {N}guyen, {T}. {T}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{C}oxiella burnetii is a pathogen causing {Q} fever. {T}he aim of our work was to study {Z}3055, a strain that is genotypically related to the strain causing the {N}etherlands outbreak. {W}e compared {Z}3055 to 5 other completed genomes available in {G}en{B}ank. {W}e calculated the blast score ratio ({BSR}) to analyze genetic differences among the strains. {T}he ratio core genome/pangenome was 98% likely other bacteria with closed pangenomes. {D}ifferences between {Z}3055 and the reference {NMI} consisted only of point mutations and insertion/deletion ({INDEL}s). {N}on-synonymous mutations significantly increased in genes coding for membrane proteins (16/156 vs 103/1757, bilateral {C}hi(2) test, p <0.05), ankyrin repeat domains containing proteins (2/9 vs 117/1904, bilateral {C}hi(2) test, p <0.05), transcription factors (7/53 vs 112/1860, bilateral {C}hi(2) test, p <0.05) and translation proteins (15/144 vs 109/1655, bilateral {C}hi(2) test, p < 0.05). {T}he evolution of this strain may have been driven by mutations in critical genes.},
  keywords = {{C}oxiella burnetii ; {Z}3055 ; {E}pidemic ; {N}etherlands ; {PAYS} {BAS}},
  booktitle = {},
  journal = {{C}omparative {I}mmunology {M}icrobiology and {I}nfectious {D}iseases},
  volume = {37},
  numero = {5-6},
  pages = {281--288},
  ISSN = {0147-9571},
  year = {2014},
  DOI = {10.1016/j.cimid.2014.08.003},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012718},
}