D'Amato F., Rouli L., Edouard S., Tyczka J., Million M., Robert C., Nguyen T. T., Raoult Didier. (2014). The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clonese. Comparative Immunology Microbiology and Infectious Diseases, 37 (5-6), p. 281-288. ISSN 0147-9571.
Titre du document
The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clonese
Année de publication
2014
Auteurs
D'Amato F., Rouli L., Edouard S., Tyczka J., Million M., Robert C., Nguyen T. T., Raoult Didier
Source
Comparative Immunology Microbiology and Infectious Diseases, 2014,
37 (5-6), p. 281-288 ISSN 0147-9571
Coxiella burnetii is a pathogen causing Q fever. The aim of our work was to study Z3055, a strain that is genotypically related to the strain causing the Netherlands outbreak. We compared Z3055 to 5 other completed genomes available in GenBank. We calculated the blast score ratio (BSR) to analyze genetic differences among the strains. The ratio core genome/pangenome was 98% likely other bacteria with closed pangenomes. Differences between Z3055 and the reference NMI consisted only of point mutations and insertion/deletion (INDELs). Non-synonymous mutations significantly increased in genes coding for membrane proteins (16/156 vs 103/1757, bilateral Chi(2) test, p <0.05), ankyrin repeat domains containing proteins (2/9 vs 117/1904, bilateral Chi(2) test, p <0.05), transcription factors (7/53 vs 112/1860, bilateral Chi(2) test, p <0.05) and translation proteins (15/144 vs 109/1655, bilateral Chi(2) test, p < 0.05). The evolution of this strain may have been driven by mutations in critical genes.
Plan de classement
Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
PAYS BAS
Identifiant IRD
PAR00012718
