@article{PAR00012711,
  title = {{T}hiazolidone derivatives as inhibitors of chikungunya virus},
  author = {{J}adav, {S}. {S}. and {S}inha, {B}. {N}. and {H}ilgenfeld, {R}. and {P}astorino, {B}. and de {L}amballerie, {X}avier and {J}ayaprakash, {V}.},
  editor = {},
  language = {{ENG}},
  abstract = {{A} series of arylalkylidene derivatives of 1,3-thiazolidin-4-one (1-20) were synthesized and tested for their antiviral activity against chikungunya virus ({LR}2006_{OPY}1) in {V}ero cell culture by {CPE} reduction assay. {F}ive compounds (7-9,16 and 19) were identified to have anti-{C}hik{V} activity at lower micro molar concentration. {T}he compounds 7, 8, 9, 16 and 19 inhibited the virus at 0.42, 4.2, 3.6, 40.1 and 6.8 mu {M} concentrations respectively. {M}olecular docking simulation has been carried out using the available {X}-ray crystal structure of the {C}hik{V} nsp2 protease, in order to elucidate the possible mechanism of action. {I}nteraction of ligands with {C}hik{V} nsp2 protease ({PDB} {C}ode: 3{TRK}) suggested the possible mechanism of protease inhibition to act as potent anti-{C}hik{V} agents.},
  keywords = {{T}hiazolidinone ; {A}ntiviral ; {C}hikungunya virus ; nsp2 protease ; {M}olecular ; docking},
  booktitle = {},
  journal = {{E}uropean {J}ournal of {M}edicinal {C}hemistry},
  volume = {89},
  numero = {},
  pages = {172--178},
  ISSN = {0223-5234},
  year = {2015},
  DOI = {10.1016/j.ejmech.2014.10.042},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012711},
}