%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Aherfi, S.
%A La Scola, B.
%A Pagnier, I.
%A Raoult, Didier
%A Colson, P.
%T The expanding family Marseilleviridae
%D 2014
%L PAR00012469
%G ENG
%J Virology
%@ 0042-6822
%K Marseillevirus ; Marseilleviridae ; Giant virus ; Megavirales ; Nucleocytoplasmic large DNA viruses ; Amoeba ; Human
%M ISI:000344208400004
%P 27-37
%R 10.1016/j.virol.2014.07.014
%U https://www.documentation.ird.fr/hor/PAR00012469
%V 466
%W Horizon (IRD)
%X The family Marseilleviridae encompasses giant viruses that replicate in free-living Acanthamoeba amoebae. Since the discovery of the founding member Marseillevirus in 2007, 7 new marseilleviruses have been observed, including 3 from environmental freshwater, one from a dipteran, and two from symptom-free humans. Marseilleviruses have approximate to 250-nm-large icosahedral capsids and 346-386-kb-long mosaic genomes that encode 444-497 predicted proteins. They share a small set of core genes with Mimivirus and other large and giant DNA viruses that compose a monophyletic group, first described in 2001. Comparative genomics analyses indicate that the family Marseilleviridae currently includes three lineages and a pan-genome composed of 600 genes. Antibodies against marseilleviruses and viral DNA have been observed in a significant proportion of asymptomatic individuals and in the blood and lymph nodes of a child with adenitis; these observations suggest that these giant viruses may be blood borne and question if they may be pathogenic in humans.
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