@article{PAR00012469, title = {{T}he expanding family {M}arseilleviridae}, author = {{A}herfi, {S}. and {L}a {S}cola, {B}. and {P}agnier, {I}. and {R}aoult, {D}idier and {C}olson, {P}.}, editor = {}, language = {{ENG}}, abstract = {{T}he family {M}arseilleviridae encompasses giant viruses that replicate in free-living {A}canthamoeba amoebae. {S}ince the discovery of the founding member {M}arseillevirus in 2007, 7 new marseilleviruses have been observed, including 3 from environmental freshwater, one from a dipteran, and two from symptom-free humans. {M}arseilleviruses have approximate to 250-nm-large icosahedral capsids and 346-386-kb-long mosaic genomes that encode 444-497 predicted proteins. {T}hey share a small set of core genes with {M}imivirus and other large and giant {DNA} viruses that compose a monophyletic group, first described in 2001. {C}omparative genomics analyses indicate that the family {M}arseilleviridae currently includes three lineages and a pan-genome composed of 600 genes. {A}ntibodies against marseilleviruses and viral {DNA} have been observed in a significant proportion of asymptomatic individuals and in the blood and lymph nodes of a child with adenitis; these observations suggest that these giant viruses may be blood borne and question if they may be pathogenic in humans.}, keywords = {{M}arseillevirus ; {M}arseilleviridae ; {G}iant virus ; {M}egavirales ; {N}ucleocytoplasmic large {DNA} viruses ; {A}moeba ; {H}uman}, booktitle = {}, journal = {{V}irology}, volume = {466}, numero = {}, pages = {27--37}, ISSN = {0042-6822}, year = {2014}, DOI = {10.1016/j.virol.2014.07.014}, URL = {https://www.documentation.ird.fr/hor/{PAR}00012469}, }