@article{PAR00012464,
  title = {{M}ultiple thyrotropin beta-subunit and thyrotropin receptor-related genes arose during vertebrate evolution},
  author = {{M}augars, {G}. and {D}ufour, {S}ylvie and {C}ohen-{T}annoudji, {J}. and {Q}uerat, {B}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}hyroid-stimulating hormone ({TSH}) is composed of a specific beta subunit and an alpha subunit that is shared with the two pituitary gonadotropins. {T}he three beta subunits derive from a common ancestral gene through two genome duplications (1{R} and 2{R}) that took place before the radiation of vertebrates. {A}nalysis of genomic data from phylogenetically relevant species allowed us to identify an additional {T}sh beta subunit-related gene that was generated through 2{R}. {T}his gene, named {T}sh beta 2, present in cartilaginous fish, little skate and elephant shark, and in early lobe-finned fish, coelacanth and lungfish, was lost in ray-finned fish and tetrapods. {T}he absence of a second type of {TSH} receptor ({T}shr) gene in these species suggests that both {TSH}s act through the same receptor. {A} novel {T}sh beta sister gene, named {T}sh beta 3, was generated through the third genomic duplication (3{R}) that occurred early in the teleost lineage. {T}sh beta 3 is present in most teleost groups but was lostin tedraodontiforms. {T}he 3{R} also generated a second {T}shr, named {T}shr beta. {I}nterestingly, the new {T}shr beta was translocated from its original chromosomic position after the emergence of eels and was then maintained in its new position. {T}shr beta was lost in tetraodontiforms and in ostariophysians including zebrafish although the latter species have two {TSH}s, suggesting that {TSHR} beta may be dispensable. {T}he tissue distribution of duplicated {T}sh beta s and {T}shrs was studied in the {E}uropean eel. {T}he endocrine thyrotropic function in the eel would be essentially mediated by the classical {T}sh beta and {T}shra, which are mainly expressed in the pituitary and thyroid, respectively. {T}sh beta 3 and {T}shr beta showed a similar distribution pattern in the brain, pituitary, ovary and adipose tissue, suggesting a possible paracrine/autocrine mode of action in these non-thyroidal tissues. {F}urther studies will be needed to determine the binding specificity of the two receptors and how these two {TSH} systems are interrelated.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {9},
  numero = {11},
  pages = {e111361},
  ISSN = {1932-6203},
  year = {2014},
  DOI = {10.1371/journal.pone.0111361},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012464},
}