@article{PAR00012376,
  title = {{A}bnormal ovarian {DNA} methylation programming during gonad maturation in wild contaminated fish},
  author = {{P}ierron, {F}. and du {C}olombier, {S}. {B}. and {M}offett, {A}. and {C}aron, {A}. and {P}eluhet, {L}. and {D}affe, {G}. and {L}ambert, {P}. and {E}lie, {P}. and {L}abadie, {P}. and {B}udzinski, {H}. and {D}ufour, {S}ylvie and {C}outure, {P}. and {B}audrimont, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}here is increasing evidence that pollutants may cause diseases via epigenetic modifications. {E}pigenetic mechanisms such as {DNA} methylation participate in the regulation of gene transcription. {S}urprisingly, epigenetics research is still limited in ecotoxicology. {I}n this study, we investigated whether chronic exposure to contaminants experienced by wild female fish ({A}nguilla anguilla) throughout their juvenile phase can affect the {DNA} methylation status of their oocytes during gonad maturation. {T}hus, fish were sampled in two locations presenting a low or a high contamination level. {T}hen, fish were transferred to the laboratory and artificially matured. {B}efore hormonal treatment, the {DNA} methylation levels of the genes encoding for the aromatase and the receptor of the follicle stimulating hormone were higher in contaminated fish than in fish from the clean site. {F}or the hormone receptor, this hypermethylation was positively correlated with the contamination level of fish and was associated with a decrease in its transcription level. {I}n addition, whereas gonad growth was associated with an increase in {DNA} methylation in fish from the clean site, no changes were observed in contaminated fish in response to hormonal treatment. {F}inally, a higher gonad growth was observed in fish from the reference site in comparison to contaminated fish.},
  keywords = {},
  booktitle = {},
  journal = {{E}nvironmental {S}cience and {T}echnology},
  volume = {48},
  numero = {19},
  pages = {11688--11695},
  ISSN = {0013-936{X}},
  year = {2014},
  DOI = {10.1021/es503712c},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012376},
}