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Pierron F., du Colombier S. B., Moffett A., Caron A., Peluhet L., Daffe G., Lambert P., Elie P., Labadie P., Budzinski H., Dufour Sylvie, Couture P., Baudrimont M. (2014). Abnormal ovarian DNA methylation programming during gonad maturation in wild contaminated fish. Environmental Science and Technology, 48 (19), 11688-11695. ISSN 0013-936X

Lien direct chez l'éditeur doi:10.1021/es503712c

Titre
Abnormal ovarian DNA methylation programming during gonad maturation in wild contaminated fish
Année de publication2014
Type de documentArticle référencé dans le Web of Science WOS:000343016600083
AuteursPierron F., du Colombier S. B., Moffett A., Caron A., Peluhet L., Daffe G., Lambert P., Elie P., Labadie P., Budzinski H., Dufour Sylvie, Couture P., Baudrimont M.
SourceEnvironmental Science and Technology, 2014, 48 (19), p. 11688-11695. ISSN 0013-936X
RésuméThere is increasing evidence that pollutants may cause diseases via epigenetic modifications. Epigenetic mechanisms such as DNA methylation participate in the regulation of gene transcription. Surprisingly, epigenetics research is still limited in ecotoxicology. In this study, we investigated whether chronic exposure to contaminants experienced by wild female fish (Anguilla anguilla) throughout their juvenile phase can affect the DNA methylation status of their oocytes during gonad maturation. Thus, fish were sampled in two locations presenting a low or a high contamination level. Then, fish were transferred to the laboratory and artificially matured. Before hormonal treatment, the DNA methylation levels of the genes encoding for the aromatase and the receptor of the follicle stimulating hormone were higher in contaminated fish than in fish from the clean site. For the hormone receptor, this hypermethylation was positively correlated with the contamination level of fish and was associated with a decrease in its transcription level. In addition, whereas gonad growth was associated with an increase in DNA methylation in fish from the clean site, no changes were observed in contaminated fish in response to hormonal treatment. Finally, a higher gonad growth was observed in fish from the reference site in comparison to contaminated fish.
Plan de classementLimnologie biologique / Océanographie biologique [034] ; Pollution [038] ; Sciences du milieu [021]
LocalisationFonds IRD
Identifiant IRDPAR00012376
Lien permanenthttp://www.documentation.ird.fr/hor/PAR00012376

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