@article{PAR00012310,
  title = {{C}omparative genomics analysis of {L}actobacillus species associated with weight gain or weight protection},
  author = {{D}rissi, {F}. and {M}erhej, {V}. and {A}ngelakis, {E}. and {E}l {K}aoutari, {A}. and {C}arriere, {F}. and {H}enrissat, {B}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{BACKGROUND}: {S}ome {L}actobacillus species are associated with obesity and weight gain while others are associated with weight loss. {L}actobacillus spp. and bifidobacteria represent a major bacterial population of the small intestine where lipids and simple carbohydrates are absorbed, particularly in the duodenum and jejunum. {T}he objective of this study was to identify {L}actobacillus spp. proteins involved in carbohydrate and lipid metabolism associated with weight modifications. {METHODS}: {W}e examined a total of 13 complete genomes belonging to seven different {L}actobacillus spp. previously associated with weight gain or weight protection. {W}e combined the data obtained from the {R}apid {A}nnotation using {S}ubsystem {T}echnology, {B}atch {CD}-{S}earch and {G}ene {O}ntology to classify gene function in each genome. {RESULTS}: {W}e observed major differences between the two groups of genomes. {W}eight gain-associated {L}actobacillus spp. appear to lack enzymes involved in the catabolism of fructose, defense against oxidative stress and the synthesis of dextrin, {L}-rhamnose and acetate. {W}eight protection-associated {L}actobacillus spp. encoded a significant gene amount of glucose permease. {R}egarding lipid metabolism, thiolases were only encoded in the genome of weight gain-associated {L}actobacillus spp. {I}n addition, we identified 18 different types of bacteriocins in the studied genomes, and weight gain-associated {L}actobacillus spp. encoded more bacteriocins than weight protection-associated {L}actobacillus spp. {CONCLUSIONS}: {T}he results of this study revealed that weight protection-associated {L}actobacillus spp. have developed defense mechanisms for enhanced glycolysis and defense against oxidative stress. {W}eight gain-associated {L}actobacillus spp. possess a limited ability to breakdown fructose or glucose and might reduce ileal brake effects.},
  keywords = {},
  booktitle = {},
  journal = {{N}utrition and {D}iabetes},
  volume = {4},
  numero = {},
  pages = {e109},
  ISSN = {2044-4052},
  year = {2014},
  DOI = {10.1038/nutd.2014.6},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012310},
}