Million M., Bellevegue L., Labussiere A. S., Dekel M., Ferry T., Deroche P., Socolovschi C., Cammilleri S., Raoult Didier. (2014). Culture-negative prosthetic joint arthritis related to Coxiella burnetii. American Journal of Medicine, 127 (8), p. 786.e7–786.e10. ISSN 0002-9343.
Titre du document
Culture-negative prosthetic joint arthritis related to Coxiella burnetii
Million M., Bellevegue L., Labussiere A. S., Dekel M., Ferry T., Deroche P., Socolovschi C., Cammilleri S., Raoult Didier
Source
American Journal of Medicine, 2014,
127 (8), p. 786.e7–786.e10 ISSN 0002-9343
BACKGROUND: The number of hip and knee arthroplasty procedures is steadily increasing as life expectancy increases. Coxiella burnetii may be responsible for culture-negative prosthetic joint arthritis and is associated with antibiotic failure and repeated surgeries. We report the first case series of C. burnetii-related culture-negative prosthetic joint arthritis. METHODS: Cases were retrieved from the French National Referral center for Q fever. Diagnosis was based on (18)fluorodeoxyglucose positron emission tomography, serology, broad-range polymerase chain reaction, and C. burnetii-specific polymerase chain reaction. RESULTS: Four cases of C. burnetii-related culture-negative prosthetic joint arthritis were found. Standard bacteriologic procedures would have missed the diagnosis in all cases. Etiologic diagnosis improved the outcome in all but 1 case. CONCLUSIONS: A systematic, comprehensive diagnostic strategy should be used in culture-negative prosthetic joint arthritis, including testing for C. burnetii in endemic areas.
