@article{PAR00012154,
  title = {{P}athogenicity and treatment of {B}artonella infections},
  author = {{A}ngelakis, {E}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}artonella spp. are responsible for emerging and re-emerging diseases around the world. {T}he majority of human infections are caused by {B}artonella henselae, {B}artonella quintana and {B}artonella bacilliformis, although other {B}artonella spp. have also been associated with clinical manifestations in humans. {T}he severity of {B}artonella infection correlates with the patient's immune status. {C}linical manifestations can range from benign and self-limited to severe and life-threatening disease. {C}linical conditions associated with {B}artonella spp. include local lymphadenopathy, bacteraemia, endocarditis, and tissue colonisation resulting in bacillary angiomatosis and peliosis hepatis. {W}ithout treatment, {B}artonella infection can cause high mortality. {T}o date, no single treatment is effective for all {B}artonella-associated diseases. {I}n the absence of systematic reviews, treatment decisions for {B}artonella infections are based on case reports that test a limited number of patients. {A}ntibiotics do not significantly affect the cure rate in patients with {B}artonella lymphadenopathy. {P}atients with {B}artonella spp. bacteraemia should be treated with gentamicin and doxycycline, but chloramphenicol has been proposed for the treatment of {B}. bacilliformis bacteraemia. {G}entamicin in combination with doxycycline is considered the best treatment regimen for endocarditis, and erythromycin is the first-line antibiotic therapy for the treatment of angioproliferative lesions. {R}ifampicin or streptomycin can be used to treat verruga peruana. {I}n this review, we present recent data and recommendations related to the treatment of {B}artonella infections based on the pathogenicity of {B}artonella spp.},
  keywords = {{B}artonella spp. ; {T}reatment ; {P}athogenicity},
  booktitle = {},
  journal = {{I}nternational {J}ournal of {A}ntimicrobial {A}gents},
  volume = {44},
  numero = {1},
  pages = {16--25},
  ISSN = {0924-8579},
  year = {2014},
  DOI = {10.1016/j.ijantimicag.2014.04.006},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012154},
}