%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Chabriere, E.
%A Gonzalez, D.
%A Azza, S.
%A Durand, P.
%A Shiekh, F. A.
%A Moal, V.
%A Baudoin, J. P.
%A Pagnier, I.
%A Raoult, Didier
%T Fetuin is the key for nanon self-propagation
%D 2014
%L PAR00012152
%G ENG
%J Microbial Pathogenesis
%@ 0882-4010
%K Nanons ; Nanobacteria ; CPP ; Self-propagating proteins ; Fetuin A ; Calcification
%M ISI:000339538200005
%P 25-30
%R 10.1016/j.micpath.2014.05.003
%U https://www.documentation.ird.fr/hor/PAR00012152
%V 73
%W Horizon (IRD)
%X "Nanobacteria", also known as nanons or calciprotein particles (CPP), are nano-sized protein mineral complexes which have been isolated from numerous biological sources. Nanons possess self-replication properties and contain only serum proteins (e.g. Fetuin-A, Albumin). Herein, we develop a simplified in vitro model of nanons propagation composed of only fetuin-A as a protein. Using this model, we demonstrate that fetuin from nanons possesses a different, non-native conformation. Moreover, we show that nanons induce soluble fetuin-A precipitation which could serve as a template for calcification. This phenomenon explains the observed self-propagating properties that mimic infectious behavior. We also demonstrate that renal calculi are capable of inducing a conformational change in fetuin-A, suggesting that the propagation phenomenon of nanons may occur in vivo.
%$ 050 ; 020