@article{PAR00012148,
  title = {{T}ropheryma whipplei and {W}hipple's disease},
  author = {{F}enollar, {F}. and {L}agier, {J}. {C}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ince its identification, information concerning {T}ropheryma whipplei, the causative agent of {W}hipple's disease ({WD}), has increased. {A}lthough {T}. whipplei is commonly infecting humans, {WD} is rare. {T}he bacterium is most likely transmitted among humans via the oro-oral and the feco-oral routes. {I}nfections result in chronic conditions such as asymptomatic carriage, disseminated {W}hipple's disease, which is usually preceded by arthralgias, and localized infections, such as endocarditis or encephalitis. {T}. whipplei is associated with acute infections including gastroenteritis, pneumonia, and/or bacteremia. {S}creening, based on the combined analyses of saliva and stool specimens using specific quantitative {PCR}, is useful if {WD} is suspected. {D}oxycycline and hydroxychloroquine for 12 months is the best treatment for {WD}; it should be followed by life-long treatment with doxycycline, as potentially fatal relapses can occur. {T}. whipplei seems to be an opportunistic bacterium that causes chronic infections in susceptible patients with as yet unknown predisposing factors.},
  keywords = {{W}hipple's disease ; {T}ropheryma whipplei ; {G}astroenteritis ; {E}ndocarditis ; {E}ncephalitis},
  booktitle = {},
  journal = {{J}ournal of {I}nfection},
  volume = {69},
  numero = {2},
  pages = {103--112},
  ISSN = {0163-4453},
  year = {2014},
  DOI = {10.1016/j.jinf.2014.05.008},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012148},
}