@article{PAR00012009,
  title = {{A}bnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment [article r{\'e}tract{\'e}]},
  author = {{A}ngelakis, {E}. and {M}illion, {M}. and {K}ankoe, {S}. and {L}agier, {J}. {C}. and {A}rmougom, {F}abrice and {G}iorgi, {R}. and {R}aoult, {D}.},
  editor = {},
  language = {{ENG}},
  abstract = {{D}oxycycline has been proposed for the treatment of malnourished children in developing countries, and its use has been associated with weight gain in healthy volunteers. {N}o previous studies have assessed abnormal weight gain as a putative side effect of long-term doxycycline treatment; thus, the objective of the present study was to characterize this phenomenon. {W}e also analyzed the role of the gut microbiota in this effect. {W}e assessed changes in the body mass index in {Q} fever endocarditis patients treated with doxycycline and hydroxychloroquine and healthy individuals with no antibiotic treatment. {A}bnormal weight gain was defined as a gain in weight above that of the controls. {T}he fecal samples were examined using molecular assays for {M}ethanobrevibacter smithii, {B}acteroidetes, {F}irmicutes, {E}scherichia coli, {L}actobacillus, {L}actobacillus reuteri, and total bacterial concentrations. {W}e examined 82 patients, including 48 patients with {Q} fever endocarditis and 34 controls. {A}pproximately 23% of the treated patients showed abnormal weight gain ({P} = 0.001). {P}atients treated with doxycycline and hydroxychloroquine presented significantly lower concentrations of {B}acteroidetes ({P} = 0.002), {F}irmicutes ({P} = 0.01), and {L}actobacillus ({P} = 0.02). {T}he linear regression analysis revealed that the duration of treatment was significantly associated with a decrease in {B}acteroidetes ({P} = 0.0001), {F}irmicutes ({P} = 0.002), and total bacteria ({P} < 0.00001). {A}bnormal weight gain is a side effect of long-term doxycycline and hydroxychloroquine treatment. {G}ut microbiota modifications at the phylum level could play an instrumental role in this effect. {W}e highlight the need for specific nutritional care in patients undergoing long-term antibiotic treatment, particularly treatment involving the use of doxycycline.},
  keywords = {},
  booktitle = {},
  journal = {{A}ntimicrobial {A}gents and {C}hemotherapy},
  volume = {58},
  numero = {6},
  pages = {3342--3347 [+ r{\'e}tractation : 2024, 68, 2, e01509--23, 1 ]},
  ISSN = {0066-4804},
  year = {2014},
  DOI = {10.1128/aac.02437-14},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00012009},
}