@article{PAR00011902,
  title = {{G}enotyping, evolution and epidemiological findings of {R}ickettsia species},
  author = {{M}erhej, {V}. and {A}ngelakis, {E}. and {S}ocolovschi, {C}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{R}ickettsiae are obligate intracellular bacteria that can cause mild to life-threatening diseases, including epidemic typhus, one of the oldest pernicious diseases of mankind. {C}linical awareness of rickettsial diseases and molecular diagnosis have shown that rickettsioses should be viewed as new emerging and reemerging diseases. {R}ickettsia has been shown to be a large genus with a worldwide distribution, a very diverse host range, including hosts that have no relationship with vertebrate. {G}enomic studies have demonstrated genome reduction due to gene loss associated with increased pathogenicity and horizontal {DNA} acquisition according to a sympatric mode of evolution in hosts that contain several organisms. {T}his article presents a review of genotyping techniques and examines the principle of genotype determination in terms of taxonomic strategies and detection methods. {T}his article summarizes the epidemiological and pathological features of {R}ickettsia and discusses the genomic findings that help the understanding of the evolution of pathogenicity including the deleterious mutations of repair systems and the toxin-antitoxin systems.},
  keywords = {{G}enotyping ; {E}volution ; {E}pidemiology ; {R}ickettsia ; {I}nfectious diseases ; {G}enomes},
  booktitle = {},
  journal = {{I}nfection {G}enetics and {E}volution},
  volume = {25},
  numero = {},
  pages = {122--137},
  ISSN = {1567-1348},
  year = {2014},
  DOI = {10.1016/j.meegid.2014.03.014},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011902},
}