%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Edouard, S.
%A Mahamat, A.
%A Demar, M.
%A Abboud, P.
%A Djossou, F.
%A Raoult, Didier
%T Comparison between emerging Q Fever in French Guiana and endemic Q fever in Marseille, France
%D 2014
%L PAR00011798
%G ENG
%J American Journal of Tropical Medicine and Hygiene
%@ 0002-9637
%K GUYANE FRANCAISE ; FRANCE
%M ISI:000335707600026
%N 5
%P 915-919
%R 10.4269/ajtmh.13-0164
%U https://www.documentation.ird.fr/hor/PAR00011798
%V 90
%W Horizon (IRD)
%X Q fever is an emergent disease in French Guiana. We compared the incidence clinical and serologic profiles between patients from Cayenne, French Guiana and Marseille in metropolitan France during a four-year period. The annual incidence of diagnosed acute Q fever was significantly higher in Cayenne (17.5/100,000) than in Marseille (1.9/100,000) (P = 0.0004), but not the annual incidence of endocarditis (1.29 versus 0.34/100,000). Most patients had fever (97%) and pneumonia (83%) in Cayenne versus 81% and 8% in Marseille (P < 0.0001 and P < 0.0001, respectively) but transaminitis was more common in patients from Marseille (54% versus 32%; P < 0.0001). The proportion of patients with cardiovascular infections was significantly lower in Cayenne (7%) than in Marseille (17%) (P = 0.017), although they showed a stronger immune response with higher levels of phase I IgG (P = 0.024). The differing epidemiology, clinical, and serologic responses of patients from Cayenne and Marseille suggest a different source of infection and a different strain of Coxiella burnetii.
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