Angelakis E., Edouard S., Lafranchi M. A., Pham T., Lafforgue P., Raoult Didier. (2014). Emergence of Q fever arthritis in France. Journal of Clinical Microbiology, 52 (4), p. 1064-1067. ISSN 0095-1137.
Angelakis E., Edouard S., Lafranchi M. A., Pham T., Lafforgue P., Raoult Didier
Source
Journal of Clinical Microbiology, 2014,
52 (4), p. 1064-1067 ISSN 0095-1137
Osteoarticular infection is an uncommon presentation of Q fever. Positron emission tomography (PET) scanning is a valuable tool for the diagnosis of Coxiella burnetii graft prosthesis infection and endocarditis. Our objective was to test a series of culture-negative osteoarticular samples using molecular assays for Coxiella burnetii. We tested for C. burnetii by molecular assays targeting the IS1111 and the IS30A spacer regions, using culture-negative osteoarticular samples obtained in our laboratory between January 2011 and December 2012. We examine a total of 1,410 osteoarticular samples, and we observed two cases of arthritis and subacromial bursitis caused by C. burnetii. The infections were localized using PET scanning, and the diagnosis was confirmed through serology. For one, a C. burnetii strain with a multispacer sequence type 8 genotype was isolated from synovial fluid culture. Q fever articular infections could be undiagnosed because of the long evolution of articular attack, and patients with high antibody titers against C. burnetii should be tested using PET scanning to localize the site of infection.
