@article{PAR00011606,
  title = {{B}acterial lymphadenitis at a major referral hospital in {F}rance from 2008 to 2012},
  author = {{S}afont, {M}. and {A}ngelakis, {E}. and {R}ichet, {H}. and {L}epidi, {H}. and {F}ournier, {P}. {E}. and {D}rancourt, {M}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{L}ymph node enlargement is a common medical problem, and in a large number of patients, the causes of lymphadenopathy remain undiagnosed. {W}e report a thorough microbiological analysis of 1,688 lymph node biopsy specimens collected in our bartonellosis reference center. {W}e studied lymph node biopsy samples from patients with suspected regional infectious lymph node enlargement from {J}anuary 2008 to {D}ecember 2012. {T}o evaluate a useful strategy for the diagnosis of infectious lymphadenitis, specimens were cultured and subjected to molecular assays. {H}istologic analysis was done when possible. {A} total of 642 (38%) biopsy specimens were infected with a bacterial agent, and quantitative {PCR} (q{PCR}) was significantly better than 16{S} r{RNA} gene {PCR} (rrs) for the detection of {B}artonella henselae ({P} = 0.05), {M}ycobacterium tuberculosis ({P} = 0.05), and {M}ycobacterium avium ({P} = 0.007). {M}olecular assays were significantly better than bacterial cultures for the diagnosis of {F}rancisella tularensis ({P} = 0.017) but were less effective for detecting {M}. tuberculosis ({P} = 0.004) and {M}. avium ({P} = 0.001). {H}istologic analysis was done for 412 lymph nodes, and 20% of these were compatible with an infectious lymphadenitis, whereas a neoplasm was found in 29% of these lymph nodes. {M}. tuberculosis was detected significantly more in female than in male patients ({P} = 0.01), and patients with cat scratch disease ({CSD}) were younger than patients with {M}. tuberculosis, {T}ropheryma whipplei, and {F}. tularensis. {N}egative rrs {PCR} does not exclude the diagnosis of infectious lymphadenitis. {H}istologic analysis of lymph node biopsy specimens is critical, as a diagnosis of infectious lymphadenitis does not preclude other concurrent diseases.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{J}ournal of {C}linical {M}icrobiology},
  volume = {52},
  numero = {4},
  pages = {1161--1167},
  ISSN = {0095-1137},
  year = {2014},
  DOI = {10.1128/jcm.03491-13},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011606},
}