@article{PAR00011497,
  title = {{G}enetic drift of {I}nfluenza {A}({H}3{N}2) viruses during two consecutive seasons in 2011-2013 in {C}orsica, {F}rance},
  author = {{F}antoni, {A}. and {A}rena, {C}. and {C}orrias, {L}. and {S}alez, {N}. and {D}e {L}amballerie, {X}avier and {A}moros, {J}. {P}. and {B}lanchon, {T}. and {V}aresi, {L}. and {F}alchi, {A}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he 2011-2012 and 2012-2013 post-pandemic influenza outbreaks were characterized by variability in the {A}({H}3{N}2) influenza viruses, resulting in low to moderate vaccine effectiveness ({VE}). {T}he aim of this study was to investigate the molecular evolution and vaccine strain match of the {A}({H}3{N}2) influenza viruses, having been circulated throughout the population of the {F}rench {C}orsica {I}sland in 2011-2012 and again in 2012-2013. {C}linical samples from 31 patients with confirmed {A}({H}3{N}2) influenza viruses were collected by general practitioners ({GP}s) over these two consecutive seasons. {A}n analysis of genetic distance and antigenic drift was conducted. {B}ased on a hemagglutinin ({HA}) aminoacid sequence analysis, the {C}orsican {A}({H}3{N}2) viruses fell into the {A}/{V}ictoria/208/2009 genetic clade, group 3. {A}ll influenza viruses were characterized by at least four fixed amino acid mutations which were: {N}145{S} (epitope {A}); {Q}156{H} and {V}186{G} (epitope {B}) {Y}219{S} (epitope {D}), with respect to the {A}/{P}erth/16/2009 (reference vaccine strain for the 2011-2012) and the {A}/{V}ictoria/361/2011 (reference vaccine strain for the 2012-2013). {U}sing the p(epitope) model, the percentages of the perfect match {VE} estimated against circulated strains declined within and between seasons, with estimations of <50%. {O}verall, these results seem to indicate an antigenic drift of the {A}({H}3{N}2) influenza viruses which were circulated in {C}orsica. {T}hese findings highlight the importance of the continuous and careful surveillance of genetic changes in the {HA} domain during seasonal influenza epidemics, in order to provide information on newly emerging genetic variants. {J}. {M}ed. {V}irol. 86:585-591, 2014.},
  keywords = {virological surveillance ; hemagglutinin ; vaccine strain ; vaccine ; effectiveness ; {FRANCE}},
  booktitle = {},
  journal = {{J}ournal of {M}edical {V}irology},
  volume = {86},
  numero = {4},
  pages = {585--591},
  ISSN = {0146-6615},
  year = {2014},
  DOI = {10.1002/jmv.23745},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011497},
}