%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Edouard, S.
%A Million, M.
%A Royer, G.
%A Giorgi, R.
%A Grisoli, D.
%A Raoult, Didier
%T Reduction in incidence of Q fever endocarditis : 27 years of experience of a national reference center
%D 2014
%L PAR00011394
%G ENG
%J Journal of Infection
%@ 0163-4453
%K Q fever ; Coxiella burnetii ; Endocarditis ; Antibioprophylaxis ; Reference center
%K FRANCE
%M ISI:000329581000005
%N 2
%P 141-148
%R 10.1016/j.jinf.2013.10.010
%U https://www.documentation.ird.fr/hor/PAR00011394
%V 68
%W Horizon (IRD)
%X Objectives: We conducted an observational study to evaluate the impact of our antibioprophylaxis protocols implemented in 2000, on the incidence of Q fever endocarditis diagnosed in our French reference center between 1985 and 2011. Methods: Endocarditis was diagnosed according to modified Duke Criteria, serological and PCR results. Our prophylaxis recommendations consist of a systematic echocardiography and an antibioprophylaxis in patients with acute Q fever and risk factors for developing endocarditis. Results: Over the last 27 years, we diagnosed 4231 acute Q fever and 818 endocarditis. Despite a significantly increased number of acute Q fever diagnoses and the use of systematic PCR testing of valves allowing serendipitous Q fever endocarditis diagnoses, we observed a decline of Q fever endocarditis. The number of cases has decreased from 316, which represents 18% of newly diagnosed cases of Q fever between 1998 and 2004, to 225, which corresponds to 11% of the cases diagnosed between 2005 and 2011. Conclusion: We believe that this decrease was a result of our strategies for prophylaxis. If this assumption is true, we may have prevented more than 150 cases of Q fever endocarditis in France over the past 10 years.
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