@article{PAR00011394,
  title = {{R}eduction in incidence of {Q} fever endocarditis : 27 years of experience of a national reference center},
  author = {{E}douard, {S}. and {M}illion, {M}. and {R}oyer, {G}. and {G}iorgi, {R}. and {G}risoli, {D}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{O}bjectives: {W}e conducted an observational study to evaluate the impact of our antibioprophylaxis protocols implemented in 2000, on the incidence of {Q} fever endocarditis diagnosed in our {F}rench reference center between 1985 and 2011. {M}ethods: {E}ndocarditis was diagnosed according to modified {D}uke {C}riteria, serological and {PCR} results. {O}ur prophylaxis recommendations consist of a systematic echocardiography and an antibioprophylaxis in patients with acute {Q} fever and risk factors for developing endocarditis. {R}esults: {O}ver the last 27 years, we diagnosed 4231 acute {Q} fever and 818 endocarditis. {D}espite a significantly increased number of acute {Q} fever diagnoses and the use of systematic {PCR} testing of valves allowing serendipitous {Q} fever endocarditis diagnoses, we observed a decline of {Q} fever endocarditis. {T}he number of cases has decreased from 316, which represents 18% of newly diagnosed cases of {Q} fever between 1998 and 2004, to 225, which corresponds to 11% of the cases diagnosed between 2005 and 2011. {C}onclusion: {W}e believe that this decrease was a result of our strategies for prophylaxis. {I}f this assumption is true, we may have prevented more than 150 cases of {Q} fever endocarditis in {F}rance over the past 10 years.},
  keywords = {{Q} fever ; {C}oxiella burnetii ; {E}ndocarditis ; {A}ntibioprophylaxis ; {R}eference center ; {FRANCE}},
  booktitle = {},
  journal = {{J}ournal of {I}nfection},
  volume = {68},
  numero = {2},
  pages = {141--148},
  ISSN = {0163-4453},
  year = {2014},
  DOI = {10.1016/j.jinf.2013.10.010},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011394},
}