@article{PAR00011392,
  title = {{E}vidence for involvement of wnt signalling in body polarities, cell proliferation, and the neuro-sensory system in an adult ctenophore},
  author = {{J}ager, {M}. and {D}ayraud, {C}. and {M}ialot, {A}. and {Q}ueinnec, {E}. and {L}e {G}uyader, {H}erv{\'e} and {M}anuel, {M}.},
  editor = {},
  language = {{ENG}},
  abstract = {{S}ignalling through the {W}nt family of secreted proteins originated in a common metazoan ancestor and greatly influenced the evolution of animal body plans. {I}n bilaterians, {W}nt signalling plays multiple fundamental roles during embryonic development and in adult tissues, notably in axial patterning, neural development and stem cell regulation. {S}tudies in various cnidarian species have particularly highlighted the evolutionarily conserved role of the {W}nt/b-catenin pathway in specification and patterning of the primary embryonic axis. {H}owever in another key non-bilaterian phylum, {C}tenophora, {W}nts are not involved in early establishment of the body axis during embryogenesis. {W}e analysed the expression in the adult of the ctenophore {P}leurobrachia pileus of 11 orthologues of {W}nt signalling genes including all ctenophore {W}nt ligands and {F}z receptors and several members of the intracellular b-catenin pathway machinery. {A}ll genes are strongly expressed around the mouth margin at the oral pole, evoking the {W}nt oral centre of cnidarians. {T}his observation is consistent with primary axis polarisation by the {W}nts being a universal metazoan feature, secondarily lost in ctenophores during early development but retained in the adult. {I}n addition, local expression of {W}nt signalling genes was seen in various anatomical structures of the body including in the locomotory comb rows, where their complex deployment suggests control by the {W}nts of local comb polarity. {O}ther important contexts of {W}nt involvement which probably evolved before the ctenophore/ cnidarian/bilaterian split include proliferating stem cells and progenitors irrespective of cell types, and developing as well as differentiated neuro-sensory structures.},
  keywords = {{FRANCE}},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {12},
  pages = {e84363},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0084363},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011392},
}