@article{PAR00011190, title = {"{M}egavirales", a proposed new order for eukaryotic nucleocytoplasmic large {DNA} viruses}, author = {{C}olson, {P}. and de {L}amballerie, {X}avier and {Y}utin, {N}. and {A}sgari, {S}. and {B}igot, {Y}. and {B}ideshi, {D}. {K}. and {C}heng, {X}. {W}. and {F}ederici, {B}. {A}. and {V}an {E}tten, {J}. {L}. and {K}oonin, {E}. {V}. and {L}a {S}cola, {B}. and {R}aoult, {D}idier}, editor = {}, language = {{ENG}}, abstract = {{T}he nucleocytoplasmic large {DNA} viruses ({NCLDV}s) comprise a monophyletic group of viruses that infect animals and diverse unicellular eukaryotes. {T}he {NCLDV} group includes the families {P}oxviridae, {A}sfarviridae, {I}ridoviridae, {A}scoviridae, {P}hycodnaviridae, {M}imiviridae and the proposed family "{M}arseilleviridae". {T}he family {M}imiviridae includes the largest known viruses, with genomes in excess of one megabase, whereas the genome size in the other {NCLDV} families varies from 100 to 400 kilobase pairs. {M}ost of the {NCLDV}s replicate in the cytoplasm of infected cells, within so-called virus factories. {T}he {NCLDV}s share a common ancient origin, as demonstrated by evolutionary reconstructions that trace approximately 50 genes encoding key proteins involved in viral replication and virion formation to the last common ancestor of all these viruses. {T}aken together, these characteristics lead us to propose assigning an official taxonomic rank to the {NCLDV}s as the order "{M}egavirales", in reference to the large size of the virions and genomes of these viruses.}, keywords = {}, booktitle = {}, journal = {{A}rchives of {V}irology}, volume = {158}, numero = {12}, pages = {2517--2521}, ISSN = {0304-8608}, year = {2013}, DOI = {10.1007/s00705-013-1768-6}, URL = {https://www.documentation.ird.fr/hor/{PAR}00011190}, }