@article{PAR00011189,
  title = {{C}odon usage, amino acid usage, transfer {RNA} and amino-acyl-t{RNA} synthetases in mimiviruses},
  author = {{C}olson, {P}. and {F}ournous, {G}. and {D}iene, {S}. {M}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{M}imiviruses are giant viruses that infect phagocytic protists, including {A}canthamoebae spp., which were discovered during the past decade. {T}hey are the current record holder among viruses for their large particle and genome sizes. {O}ne group is composed of three lineages, referred to as {A}, {B} and {C}, which include the vast majority of the {M}imiviridae members. {C}afeteria roenbergensis virus represents a second group, though the {M}imiviridae family is still expanding. {W}e analyzed the codon and amino acid usages in mimiviruses, as well as both the transfer {RNA} (t{RNA}) and amino acyl-t{RNA} synthetases. {W}e confirmed that the codon and amino acid usages of these giant viruses are highly dissimilar to those in their amoebal host {A}canthamoeba castellanii and are instead correlated with the high adenine and thymine ({AT}) content of {M}imivirus genomes. {W}e further describe that the set of t{RNA}s and amino acyl-t{RNA} synthetases in mimiviruses is globally not adapted to the codon and amino acid usages of these viruses. {N}otwithstanding, {L}eu({TAA})t{RNA}, present in several {M}imivirus genomes and in multiple copies in some viral genomes, may complement the amoebal t{RNA} pool and may contribute to accommodate the viral {AT}-rich codons. {I}n addition, we found that the genes most highly expressed at the beginning of the {M}imivirus replicative cycle have a nucleotide content more adapted to the codon usage in {A}. castellanii.},
  keywords = {{M}imiviridae ; {M}imivirus ; {C}odon usage ; {C}odon bias ; {A}canthamoeba spp. ; {A}moeba ; {M}arseillevirus ; {M}arseilleviridae ; {M}egavirales ; {N}ucleocytoplasmic ; large {DNA} viruses},
  booktitle = {},
  journal = {{I}ntervirology},
  volume = {56},
  numero = {6},
  pages = {364--375},
  ISSN = {0300-5526},
  year = {2013},
  DOI = {10.1159/000354557},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011189},
}