@article{PAR00011184,
  title = {{W}eight loss, dementia and ataxia susceptible to doxycycline : a likely new case report caused by {T}. whipplei},
  author = {{L}agier, {J}. {C}. and {F}enollar, {F}. and {K}oric, {L}. and {G}uedj, {E}. and {C}eccaldi, {M}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{I}ntroduction. - {W}hipple's disease is a rare infectious disease due to {T}ropheryma whipplei, a bacterium rarely causing severe localized neurological infection (only 25 cases reported in the literature), which are more often diagnosed by a positive {T}. whipplei {PCR} performed on cerebrospinal fluid. {C}ase report. - {W}e report the third case of progressive dementia associated with obesity and ataxia in a 52-year-old man. {C}lassic laboratory results performed to identify the etiology of the clinical features were non-contributive: only a saliva {T}. whipplei {PCR} was strongly positive and the {W}estern blot serology has detected an asymptomatic carriage profile. {T}he (18){FDG}-{PET} highlighted a frontal area hypometabolism. {A}n antibiotic treatment by doxycycline allowed a partial regression of the neurological manifestations, a weight loss and a significant improvement of the (18){FDG} frontal hypometabolism. {C}onclusion. - {P}rogressive dementia associated with ataxia and obesity is a new clinical syndrome caused by {T}. whipplei. {A}ntibiotic test by doxycycline can help to the diagnosis and (18)-{FDG} could facilitate the follow-up.},
  keywords = {{T}ropheryma whipplei ; {W}hipple's disease ; {D}oxycyclin ; (18){FDG}-{PET}},
  booktitle = {},
  journal = {{R}evue de {M}edecine {I}nterne},
  volume = {34},
  numero = {10},
  pages = {641--644},
  ISSN = {0248-8663},
  year = {2013},
  DOI = {10.1016/j.revmed.2012.12.006},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011184},
}