%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Popgeorgiev, N.
%A Michel, G.
%A Lepidi, H.
%A Raoult, Didier
%A Desnues, C.
%T Marseillevirus Adenitis in an 11-Month-Old Child
%D 2013
%L PAR00011177
%G ENG
%J Journal of Clinical Microbiology
%@ 0095-1137
%M ISI:000327147100033
%N 12
%P 4102-4105
%R 10.1128/jcm.01918-13
%U https://www.documentation.ird.fr/hor/PAR00011177
%V 51
%W Horizon (IRD)
%X A Marseillevirus (giant virus of amoeba) has been found in the blood and stool samples of individuals who otherwise appear to be healthy. During an attempt to define a serological cutoff for Marseillevirus by enzyme-linked immunosorbent assay (ELISA) in children, we serendipitously detected high antibody responses to Marseillevirus in an 11-month-old boy suffering from adenitis. Marseillevirus DNA was then found in his blood using PCR and with a unique sequence. We identified Marseillevirus in a lymph node using fluorescence in situ hybridization (FISH) and immunohistochemistry, and the lymph node was removed surgically. The child was declared to be cured 1 year later. We conclude that adenitis during early childhood may be caused by Marseillevirus.
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