@article{PAR00011064,
  title = {{U}se of the plaque assay for testing the antibiotic susceptibility of intracellular bacteria},
  author = {{E}douard, {S}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he plaque assay was first described for titration of bacterial inoculums and clonal isolation, and was later adapted for testing antibiotics susceptibility and to study virulence factors and motility of bacteria. {O}ver time, the sensitivity and reproducibility of the technique has been improved. {U}sually, the number of plaques is counted; however, the recent development of informatics tools has stimulated interest in the quantification of plaque size. {O}wing to this new approach, the plaque assay has been used to characterize the host cell response when infected cells are treated with antimicrobial agents. {I}t was found that statins prevented cell lesions following rickettsial infection; in other studies, some antibiotics were found to cause apoptosis of host cells, suggesting a toxic activity. {H}ere, we present an overview of the plaque assay as it has been used to investigate intracellular bacteria.},
  keywords = {antibiotic ; {C}oxiella burnetii ; intracellular bacteria ; plaque assay ; {R}ickettsia ; statin ; toxin ; virulence},
  booktitle = {},
  journal = {{F}uture {M}icrobiology},
  volume = {8},
  numero = {10},
  pages = {1301--1316},
  ISSN = {1746-0913},
  year = {2013},
  DOI = {10.2217/fmb.13.98},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011064},
}