@article{PAR00011058,
  title = {{M}arseillevirus-like virus recovered from blood donated by asymptomatic humans},
  author = {{P}opgeorgiev, {N}. and {B}oyer, {M}. and {F}ancello, {L}. and {M}onteil, {S}. and {R}obert, {C}. and {R}ivet, {R}. and {N}appez, {C}. and {A}zza, {S}. and {C}hiaroni, {J}. and {R}aoult, {D}idier and {D}esnues, {C}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he study of the human virome is still in its infancy, especially with regard to the viral content of the blood of people who are apparently disease free. {I}n this study, the genome of a new giant virus that is related to the amoeba-infecting pathogen {M}arseillevirus was recovered from donated blood, using high-throughput sequencing. {V}iral antigens were identified by an immunoconversion assay. {T}he virus was visualized with transmission electron microscopy and fluorescence in situ hybridization and was grown in human {T} lymphocytes. {S}pecific antibody reactions were used to identify viral proteins in blood specimens from polymerase chain reactive-positive donors. {F}inally, we tested 20 blood specimens from additional donors. {T}hree had antibodies directed against this virus, and 2 had circulating viral {DNA}. {T}his study shows that giant viruses, which are missed by the use of ultrafilters, are part of the human blood virome. {T}he putative pathogenic role of giant viruses in humans remains undefined.},
  keywords = {viral metagenomics ; giant viruses ; {M}arseillevirus ; blood virome},
  booktitle = {},
  journal = {{J}ournal of {I}nfectious {D}iseases},
  volume = {208},
  numero = {7},
  pages = {1042--1050},
  ISSN = {0022-1899},
  year = {2013},
  DOI = {10.1093/infdis/jit292},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011058},
}