@article{PAR00011053,
  title = {{H}eteroplasmy in the mitochondrial genomes of human lice and ticks revealed by high throughput sequencing},
  author = {{X}iong, {H}. {Y}. and {B}arker, {S}. {C}. and {B}urger, {T}. {D}. and {R}aoult, {D}idier and {S}hao, {R}. {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}he typical mitochondrial (mt) genomes of bilateral animals consist of 37 genes on a single circular chromosome. {T}he mt genomes of the human body louse, {P}ediculus humanus, and the human head louse, {P}ediculus capitis, however, are extensively fragmented and contain 20 minichromosomes, with one to three genes on each minichromosome. {H}eteroplasmy, i.e. nucleotide polymorphisms in the mt genome within individuals, has been shown to be significantly higher in the mt cox1 gene of human lice than in humans and other animals that have the typical mt genomes. {T}o understand whether the extent of heteroplasmy in human lice is associated with mt genome fragmentation, we sequenced the entire coding regions of all of the mt minichromosomes of six human body lice and six human head lice from {E}thiopia, {C}hina and {F}rance with an {I}llumina {H}i{S}eq platform. {F}or comparison, we also sequenced the entire coding regions of the mt genomes of seven species of ticks, which have the typical mitochondrial genome organization of bilateral animals. {W}e found that the level of heteroplasmy varies significantly both among the human lice and among the ticks. {T}he human lice from {E}thiopia have significantly higher level of heteroplasmy than those from {C}hina and {F}rance ({P}-t<0.05). {T}he tick, {A}mblyomma cajennense, has significantly higher level of heteroplasmy than other ticks ({P}-t<0.05). {O}ur results indicate that heteroplasmy level can be substantially variable within a species and among closely related species, and does not appear to be determined by single factors such as genome fragmentation.},
  keywords = {},
  booktitle = {},
  journal = {{P}los {O}ne},
  volume = {8},
  numero = {9},
  pages = {e73329},
  ISSN = {1932-6203},
  year = {2013},
  DOI = {10.1371/journal.pone.0073329},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00011053},
}