%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Peeters, Martine
%A Jung, M.
%A Ayouba, Ahidjo
%T The origin and molecular epidemiology of HIV
%D 2013
%L PAR00011046
%G ENG
%J Expert Review of Anti-Infective Therapy
%@ 1478-7210
%K cross-species transmission ; drug resistance ; evolution ; HIV-1 ; HIV-2 ; molecular epidemiology ; recombinant ; SIV ; subtype
%K AFRIQUE CENTRALE ; AFRIQUE DE L'OUEST
%M ISI:000324648500010
%N 9
%P 885-896
%R 10.1586/14787210.2013.825443
%U https://www.documentation.ird.fr/hor/PAR00011046
%> https://www.documentation.ird.fr/intranet/publi/2021-11/010083649.pdf
%V 11
%W Horizon (IRD)
%X HIV-1 in humans resulted from at least four cross-species transmissions of simian immunodeficiency viruses (SIVs) from chimpanzees and gorillas in West Central Africa, while HIV-2 viruses resulted from at least eight independent transmissions of SIVs infecting sooty mangabeys in West Africa only, where one of these transmissions (HIV-1 group M) is responsible for the global epidemic. HIV-1 M is subdivided into nine subtypes and a wide diversity of circulating recombinant forms (CRFs) and unique recombinant forms. The heterogenic HIV-1 M subtype/CRF distribution is the result of founder effects. The genetic diversity of HIV-1 continues to increase overtime due to demographic factors such as travel and migration and frequent co/superinfections. In addition, the expanded access to antiretrovirals leads to an increasing number of drug-resistant strains, especially in resource limited countries.
%$ 052 ; 080