%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Hraiech, S.
%A Roch, A.
%A Lepidi, H.
%A Atieh, T.
%A Audoly, G.
%A Rolain, J. M.
%A Raoult, Didier
%A Brunel, J. M.
%A Papazian, L.
%A Bregeon, F.
%T Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat Model of pneumonia
%D 2013
%L PAR00010935
%G ENG
%J Antimicrobial Agents and Chemotherapy
%@ 0066-4804
%M ISI:000324480300065
%N 10
%P 5120-5121
%R 10.1128/aac.00700-13
%U https://www.documentation.ird.fr/hor/PAR00010935
%V 57
%W Horizon (IRD)
%X We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).
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