Hraiech S., Roch A., Lepidi H., Atieh T., Audoly G., Rolain J. M., Raoult Didier, Brunel J. M., Papazian L., Bregeon F. (2013). Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat Model of pneumonia. Antimicrobial Agents and Chemotherapy, 57 (10), p. 5120-5121. ISSN 0066-4804.
Titre du document
Impaired virulence and fitness of a colistin-resistant clinical isolate of Acinetobacter baumannii in a rat Model of pneumonia
Hraiech S., Roch A., Lepidi H., Atieh T., Audoly G., Rolain J. M., Raoult Didier, Brunel J. M., Papazian L., Bregeon F.
Source
Antimicrobial Agents and Chemotherapy, 2013,
57 (10), p. 5120-5121 ISSN 0066-4804
We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).
Plan de classement
Santé : généralités [050]
;
Sciences du monde animal [080]
;
Biotechnologies [084]
