@article{PAR00010831,
  title = {{P}ostgenomic analysis of bacterial pathogens repertoire reveals genome reduction rather than virulence factors},
  author = {{M}erhej, {V}. and {G}eorgiades, {K}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{I}n the pregenomic era, the acquisition of pathogenicity islands via horizontal transfer was proposed as a major mechanism in pathogen evolution. {M}uch effort has been expended to look for the contiguous blocks of virulence genes that are present in pathogenic bacteria, but absent in closely related species that are nonpathogenic. {H}owever, some of these virulence factors were found in nonpathogenic bacteria. {M}oreover, and contrary to expectation, pathogenic bacteria were found to lack genes (antivirulence genes) that are characteristic of nonpathogenic bacteria. {T}he availability of complete genome sequences has led to a new era of pathogen research. {C}omparisons of genomes have shown that the most pathogenic bacteria have reduced genomes, with less ribosomal {RNA} and unorganized operons; they lack transcriptional regulators but have more genes that encode protein toxins, toxin-antitoxin ({TA}) modules, and proteins for {DNA} replication and repair, when compared with less pathogenic close relatives. {T}hese findings questioned the paradigm of virulence by gene acquisition and put forward the notion of genomic repertoire of virulence.},
  keywords = {microbial genomics ; reductive evolution ; pathogenicity ; antivirulence ; genes ; toxin},
  booktitle = {},
  journal = {{B}riefings in {F}unctional {G}enomics},
  volume = {12},
  numero = {4},
  pages = {291--304},
  ISSN = {2041-2649},
  year = {2013},
  DOI = {10.1093/bfgp/elt015},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010831},
}