@article{PAR00010729,
  title = {{I}mmunoglobulin {G} anticardiolipin antibodies and progression to {Q} fever endocarditis},
  author = {{M}illion, {M}. and {W}alter, {G}. and {B}ardin, {N}. and {C}amoin, {L}. and {G}iorgi, {R}. and {B}ongrand, {P}. and {G}ouriet, {F}. and {C}asalta, {J}. {P}. and {T}huny, {F}. and {H}abib, {G}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground. {I}mmunoglobulin {G} ({I}g{G}) anticardiolipin (a{CL}) antibodies are associated with valvulopathy and endocarditis in patients with lupus and other diseases. {D}uring acute {Q} fever, high {I}g{G} a{CL} prevalence has been reported, but the clinical significance remains unknown. {M}ethods. {T}o test if increased {I}g{G} a{CL} at acute {Q} fever diagnosis is associated with an increased risk of progression to endocarditis, all patients diagnosed in the {F}rench {N}ational {R}eferral {C}enter for {Q} fever from {J}anuary 2007 to {D}ecember 2011 were included and followed regularly until {J}anuary 2013 in a 5-year prospective cohort study. {Q} fever endocarditis was defined according to recently updated criteria. {R}esults. {S}eventy-two patients were followed for a median time of 31 months (interquartile range, 18-47 months). {O}f these, 13 patients with valvulopathy without antibiotic prophylaxis progressed to endocarditis. {I}g{G} a{CL} levels were highly prevalent (57%) and significantly higher in the presence of a valvulopathy ({P} =.005). {U}sing {C}ox regression analysis, highly increased levels of {I}g{G} a{CL} (adjusted hazard ratio [{AHR}], 12.95; 95% confidence interval, 2.85-58.95; {P} =.001) and high levels of phase {II} immunoglobulin {M} ({I}g{M}; {AHR}, 6.59; 95% {CI}, 1.37-31.62; {P} =.018) were the only independent predictors of progression to endocarditis. {C}onclusions. {R}apid progression from acute {Q} fever to endocarditis is associated with high levels of {I}g{G} a{CL} and high levels of phase {II} {I}g{M}, findings that should be critical in the prevention of endocarditis.},
  keywords = {{Q} fever ; {C}oxiella burnetii ; antiphospholipid ; anticardiolipin ; endocarditis},
  booktitle = {},
  journal = {{C}linical {I}nfectious {D}iseases},
  volume = {57},
  numero = {1},
  pages = {57--64},
  ISSN = {1058-4838},
  year = {2013},
  DOI = {10.1093/cid/cit191},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010729},
}