%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Najahi, E.
%A Valentin, A.
%A Tene, N.
%A Treilhou, M.
%A Nepveu, Françoise
%T Synthesis and biological evaluation of new bis-indolone-N-oxides
%D 2013
%L PAR00010728
%G ENG
%J Bioorganic Chemistry
%@ 0045-2068
%K Bis-indolone-N-oxides ; Plasmodium falciparum ; Bacteria ; Cytotoxicity
%M ISI:000320652800003
%P 16-21
%R 10.1016/j.bioorg.2013.03.001
%U https://www.documentation.ird.fr/hor/PAR00010728
%V 48
%W Horizon (IRD)
%X A series of bis-indolone-N-oxides, 1a-f, was prepared from bis(ethynyl)benzenes and o-halonitroaryls and studied for their in vitro antiplasmodial activities against Plasmodium falciparum and representative strains of bacteria and candida as well as for their cytotoxicity against a human tumor cell line (MCF7). They did not cause any haemolysis (300 mu g mL(-1)). Of the synthesized bis-indolones, compound 1a had the most potent antiplasmodial activity (IC50 = 0.763 mu mol L-1 on the FcB1 strain) with a selectivity index (CC50 MCF7/IC50 FcB1) of 35.6. No potency against the tested microbial strains was observed.
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