@article{PAR00010728,
  title = {{S}ynthesis and biological evaluation of new bis-indolone-{N}-oxides},
  author = {{N}ajahi, {E}. and {V}alentin, {A}. and {T}ene, {N}. and {T}reilhou, {M}. and {N}epveu, {F}ran{\c{c}}oise},
  editor = {},
  language = {{ENG}},
  abstract = {{A} series of bis-indolone-{N}-oxides, 1a-f, was prepared from bis(ethynyl)benzenes and o-halonitroaryls and studied for their in vitro antiplasmodial activities against {P}lasmodium falciparum and representative strains of bacteria and candida as well as for their cytotoxicity against a human tumor cell line ({MCF}7). {T}hey did not cause any haemolysis (300 mu g m{L}(-1)). {O}f the synthesized bis-indolones, compound 1a had the most potent antiplasmodial activity ({IC}50 = 0.763 mu mol {L}-1 on the {F}c{B}1 strain) with a selectivity index ({CC}50 {MCF}7/{IC}50 {F}c{B}1) of 35.6. {N}o potency against the tested microbial strains was observed.},
  keywords = {{B}is-indolone-{N}-oxides ; {P}lasmodium falciparum ; {B}acteria ; {C}ytotoxicity},
  booktitle = {},
  journal = {{B}ioorganic {C}hemistry},
  volume = {48},
  numero = {},
  pages = {16--21},
  ISSN = {0045-2068},
  year = {2013},
  DOI = {10.1016/j.bioorg.2013.03.001},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010728},
}