@article{PAR00010717,
  title = {{P}roteomics : a new way to improve human {A}frican trypanosomiasis diagnosis ?},
  author = {{H}olzmuller, {P}. and {G}r{\'e}baut, {P}ascal and {S}emballa, {S}. and {G}onzatti, {M}. {I}. and {G}eiger, {A}nne},
  editor = {},
  language = {{ENG}},
  abstract = {{A}frican trypanosomiases, including the human disease referred to as 'sleeping sickness' and the animal diseases such as nagana, surra and dourine, are neglected vector-borne diseases that after years of research still need improved diagnosis and chemotherapy. {A}dvances in proteomics offer new tools to define biomarkers, whose expression may reflect host-parasite interactions occurring during the infection. {I}n this review, the authors first describe the current diagnostic tools used to detect a trypanosome infection during field surveys, and then discuss their interests, limits and further evolutions. {T}he authors also report on the contribution of molecular diagnostics, and the recent advances and developments that make it suitable for fieldwork. {T}he authors then explore the recent uses of proteomics technology to define host and parasite biomarkers that allow detection of the infection, the power and constraints of the technology. {T}he authors conclude by discussing the urgent need to use the biomarkers discovered in order to develop tools to improve trypanosomiasis control in the near future.},
  keywords = {animal trypanosomosis ; human {A}frican trypanosomiasis ; molecular diagnosis ; proteomics ; serodiagnosis ; {AFRIQUE}},
  booktitle = {},
  journal = {{E}xpert {R}eview of {P}roteomics},
  volume = {10},
  numero = {3},
  pages = {289--301},
  ISSN = {1478-9450},
  year = {2013},
  DOI = {10.1586/epr.13.14},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010717},
}