@article{PAR00010401,
  title = {{M}orbidity after antiretroviral therapy initiation in {HIV}-1-infected children in {W}est {A}frica : temporal trends and relation to {CD}4 count},
  author = {{B}eaudrap, {P}ierre de and {B}oulle, {C}. and {L}ewden, {C}. and {G}abillard, {D}. and {N}acro, {B}. and {D}iagbouga, {S}. and {F}assinou, {P}. and {H}ien, {H}. and {L}aurent, {C}hristian and {M}sellati, {P}hilippe},
  editor = {},
  language = {{ENG}},
  abstract = {{B}ackground: {A}lthough 90% of {HIV}-1-infected children live in sub-{S}aharan {A}frica, morbidity data after highly active antiretroviral therapy ({HAART}) initiation in these settings are limited. {T}he objective of this study was to document the incidence of {AIDS}-defining events and non-{AIDS}-defining diseases in {A}frican children receiving {HAART}. {M}ethods: {I}ncidences rates ({IR}s) of {AIDS}-defining events and 10 other common diseases were estimated overall and by current {CD}4-strata (<15%, 15-<25% and >= 25%) from 2 prospective cohorts of {A}frican -children. {R}esults: {O}ne hundred eighty-eight children contributing to 355 children-years were included. {T}he documented morbidity {IR}s per 100 children-years were upper respiratory infections, 100 (87-114); infectious diarrhea, 37 (31-44); {W}orld {H}ealth {O}rganization ({WHO}) stage 2 events, 22.9 (18.2-28.1); and {WHO} stage 3/4 events, 12.3 (9.1-16.7). {IR}s of {WHO} stage 2 events, severe bacterial infections, infectious diarrhea and pneumonia decreased linearly across all {CD}4%-strata, whereas {WHO} stage 3/4 events and viral infections occurred mostly when {CD}4% <15%. {O}verall, {IR}s decreased during the first 2 years on {HAART} except for upper respiratory infection, mycosis and oral candidiasis. {C}onclusion: {T}his incidence of {AIDS}-and non-{AIDS}-defining diseases declined substantially after {HAART} in 2 {A}frican cohorts, although estimates remained high compared with high-resource settings. {W}ithout renewed efforts to increase antiretroviral scale-up, children in developing countries will continue to have a high burden of infections.},
  keywords = {{HIV} ; children ; highly active antiretroviral therapy ; {AIDS}-defining ; infection ; morbidity ; {AFRIQUE} {DE} {L}'{OUEST}},
  booktitle = {},
  journal = {{P}ediatric {I}nfectious {D}isease {J}ournal},
  volume = {32},
  numero = {4},
  pages = {354--360},
  ISSN = {0891-3668},
  year = {2013},
  DOI = {10.1097/{INF}.0b013e318278b222},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010401},
}