Publications des scientifiques de l'IRD

Beaudrap Pierre de, Boulle C., Lewden C., Gabillard D., Nacro B., Diagbouga S., Fassinou P., Hien H., Laurent Christian, Msellati Philippe. (2013). Morbidity after antiretroviral therapy initiation in HIV-1-infected children in West Africa : temporal trends and relation to CD4 count. Pediatric Infectious Disease Journal, 32 (4), p. 354-360. ISSN 0891-3668.

Titre du document
Morbidity after antiretroviral therapy initiation in HIV-1-infected children in West Africa : temporal trends and relation to CD4 count
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000316669200021
Auteurs
Beaudrap Pierre de, Boulle C., Lewden C., Gabillard D., Nacro B., Diagbouga S., Fassinou P., Hien H., Laurent Christian, Msellati Philippe
Source
Pediatric Infectious Disease Journal, 2013, 32 (4), p. 354-360 ISSN 0891-3668
Background: Although 90% of HIV-1-infected children live in sub-Saharan Africa, morbidity data after highly active antiretroviral therapy (HAART) initiation in these settings are limited. The objective of this study was to document the incidence of AIDS-defining events and non-AIDS-defining diseases in African children receiving HAART. Methods: Incidences rates (IRs) of AIDS-defining events and 10 other common diseases were estimated overall and by current CD4-strata (<15%, 15-<25% and >= 25%) from 2 prospective cohorts of African -children. Results: One hundred eighty-eight children contributing to 355 children-years were included. The documented morbidity IRs per 100 children-years were upper respiratory infections, 100 (87-114); infectious diarrhea, 37 (31-44); World Health Organization (WHO) stage 2 events, 22.9 (18.2-28.1); and WHO stage 3/4 events, 12.3 (9.1-16.7). IRs of WHO stage 2 events, severe bacterial infections, infectious diarrhea and pneumonia decreased linearly across all CD4%-strata, whereas WHO stage 3/4 events and viral infections occurred mostly when CD4% <15%. Overall, IRs decreased during the first 2 years on HAART except for upper respiratory infection, mycosis and oral candidiasis. Conclusion: This incidence of AIDS-and non-AIDS-defining diseases declined substantially after HAART in 2 African cohorts, although estimates remained high compared with high-resource settings. Without renewed efforts to increase antiretroviral scale-up, children in developing countries will continue to have a high burden of infections.
Plan de classement
Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
AFRIQUE DE L'OUEST
Localisation
Fonds IRD
Identifiant IRD
PAR00010401
Contact