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Beaudrap Pierre de, Boulle C., Lewden C., Gabillard D., Nacro B., Diagbouga S., Fassinou P., Hien H., Laurent Christian, Msellati Philippe. (2013). Morbidity after antiretroviral therapy initiation in HIV-1-infected children in West Africa : temporal trends and relation to CD4 count. Pediatric Infectious Disease Journal, 32 (4), 354-360. ISSN 0891-3668

Lien direct chez l'éditeur doi:10.1097/INF.0b013e318278b222

Titre
Morbidity after antiretroviral therapy initiation in HIV-1-infected children in West Africa : temporal trends and relation to CD4 count
Année de publication2013
Type de documentArticle référencé dans le Web of Science WOS:000316669200021
AuteursBeaudrap Pierre de, Boulle C., Lewden C., Gabillard D., Nacro B., Diagbouga S., Fassinou P., Hien H., Laurent Christian, Msellati Philippe.
SourcePediatric Infectious Disease Journal, 2013, 32 (4), p. 354-360. ISSN 0891-3668
RésuméBackground: Although 90% of HIV-1-infected children live in sub-Saharan Africa, morbidity data after highly active antiretroviral therapy (HAART) initiation in these settings are limited. The objective of this study was to document the incidence of AIDS-defining events and non-AIDS-defining diseases in African children receiving HAART. Methods: Incidences rates (IRs) of AIDS-defining events and 10 other common diseases were estimated overall and by current CD4-strata (<15%, 15-<25% and >= 25%) from 2 prospective cohorts of African -children. Results: One hundred eighty-eight children contributing to 355 children-years were included. The documented morbidity IRs per 100 children-years were upper respiratory infections, 100 (87-114); infectious diarrhea, 37 (31-44); World Health Organization (WHO) stage 2 events, 22.9 (18.2-28.1); and WHO stage 3/4 events, 12.3 (9.1-16.7). IRs of WHO stage 2 events, severe bacterial infections, infectious diarrhea and pneumonia decreased linearly across all CD4%-strata, whereas WHO stage 3/4 events and viral infections occurred mostly when CD4% <15%. Overall, IRs decreased during the first 2 years on HAART except for upper respiratory infection, mycosis and oral candidiasis. Conclusion: This incidence of AIDS-and non-AIDS-defining diseases declined substantially after HAART in 2 African cohorts, although estimates remained high compared with high-resource settings. Without renewed efforts to increase antiretroviral scale-up, children in developing countries will continue to have a high burden of infections.
Plan de classementEntomologie médicale / Parasitologie / Virologie [052] ; Santé : généralités [050]
Descr. géo.AFRIQUE DE L'OUEST
LocalisationFonds IRD
Identifiant IRDPAR00010401
Lien permanenthttp://www.documentation.ird.fr/hor/PAR00010401

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