@article{PAR00010214,
  title = {{I}dentification of salivary antigenic markers discriminating host exposition between two {E}uropean ticks : {R}hipicephalus sanguineus and {D}ermacentor reticulatus},
  author = {{H}ai, {V}. {V}. and {A}lmeras, {L}. and {A}udebert, {S}. and {P}ophillat, {M}. and {B}oulanger, {N}. and {P}arola, {P}. and {R}aoult, {D}idier and {P}ages, {F}.},
  editor = {},
  language = {{ENG}},
  abstract = {{T}o succeed blood meal, ticks inject salivary proteins to mammalian hosts, eliciting an antibody response against these foreign antigens. {A}lthough this immune response has been proposed as a surrogate marker of exposure to tick bites, identification of the corresponding antigens remains elusive. {F}or this aim, a comparison by immunoblots of the kinetic {I}g{G} responses to protein salivary gland extracts from two {E}uropean tick species, {R}hipicephalus sanguineus or {D}ermacentor reticulatus, in rabbits was performed. {A} singularity in the immune patterns was observed according to rabbit exposure status and depending on the antigen source. {S}ix and five bands were found specifically associated to {R}. sanguineus and to {D}. reticulatus exposures, respectively. {T}he identity of these salivary antigenic proteins was determined using an original immunoproteomic approach. {T}he utilization of these tick salivary proteins as biomarker candidates to discriminate {R}. sanguineus and/or {D}. reticulatus tick exposure or to develop anti-tick vaccines is discussed.},
  keywords = {{T}ick-borne diseases ; {R}hipicephalus sanguineus ; {D}ermacentor reticulatus ; {S}alivary antigens ; {E}xposure markers ; {V}accine candidates ; {EUROPE}},
  booktitle = {},
  journal = {{C}omparative {I}mmunology {M}icrobiology and {I}nfectious {D}iseases},
  volume = {36},
  numero = {1},
  pages = {39--53},
  ISSN = {0147-9571},
  year = {2013},
  DOI = {10.1016/j.cimid.2012.09.003},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010214},
}