Publications des scientifiques de l'IRD

Hai V. V., Almeras L., Audebert S., Pophillat M., Boulanger N., Parola P., Raoult Didier, Pages F. (2013). Identification of salivary antigenic markers discriminating host exposition between two European ticks : Rhipicephalus sanguineus and Dermacentor reticulatus. Comparative Immunology Microbiology and Infectious Diseases, 36 (1), p. 39-53. ISSN 0147-9571.

Titre du document
Identification of salivary antigenic markers discriminating host exposition between two European ticks : Rhipicephalus sanguineus and Dermacentor reticulatus
Année de publication
2013
Type de document
Article référencé dans le Web of Science WOS:000314319800005
Auteurs
Hai V. V., Almeras L., Audebert S., Pophillat M., Boulanger N., Parola P., Raoult Didier, Pages F.
Source
Comparative Immunology Microbiology and Infectious Diseases, 2013, 36 (1), p. 39-53 ISSN 0147-9571
To succeed blood meal, ticks inject salivary proteins to mammalian hosts, eliciting an antibody response against these foreign antigens. Although this immune response has been proposed as a surrogate marker of exposure to tick bites, identification of the corresponding antigens remains elusive. For this aim, a comparison by immunoblots of the kinetic IgG responses to protein salivary gland extracts from two European tick species, Rhipicephalus sanguineus or Dermacentor reticulatus, in rabbits was performed. A singularity in the immune patterns was observed according to rabbit exposure status and depending on the antigen source. Six and five bands were found specifically associated to R. sanguineus and to D. reticulatus exposures, respectively. The identity of these salivary antigenic proteins was determined using an original immunoproteomic approach. The utilization of these tick salivary proteins as biomarker candidates to discriminate R. sanguineus and/or D. reticulatus tick exposure or to develop anti-tick vaccines is discussed.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020] ; Santé : généralités [050] ; Entomologie médicale / Parasitologie / Virologie [052]
Description Géographique
EUROPE
Localisation
Fonds IRD
Identifiant IRD
PAR00010214
Contact