%0 Journal Article
%9 ACL : Articles dans des revues avec comité de lecture répertoriées par l'AERES
%A Kempf, M.
%A Rolain, J. M.
%A Azza, S.
%A Diene, S.
%A Joly-Guillou, M. L.
%A Dubourg, G.
%A Colson, P.
%A Papazian, L.
%A Richet, H.
%A Fournier, P. E.
%A Ribeiro, A.
%A Raoult, Didier
%T Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France : a transition from an epidemic to an endemic situation
%D 2013
%L PAR00010117
%G ENG
%J Apmis
%@ 0903-4641
%K Acinetobacter baumannii ; multidrug resistant bacteria ; pulsed-field gel ; electrophoresis ; bla(OXA23-like) ; endemic ; outbreak
%K FRANCE
%M ISI:000313830600008
%N 1
%P 64-71
%R 10.1111/j.1600-0463.2012.02935.x
%U https://www.documentation.ird.fr/hor/PAR00010117
%V 121
%W Horizon (IRD)
%X Kempf M, Rolain J-M, Azza S, Diene S, Joly-Guillou M-L, Dubourg G, Colson P, Papazian L, Richet H, Fournier P-E, Ribeiro A, Raoult D. Investigation of Acinetobacter baumannii resistance to carbapenems in Marseille hospitals, south of France: a transition from an epidemic to an endemic situation. APMIS 2013; 121: 64-71. Carbapenem-resistant Acinetobacter baumannii infections are a worldwide endemic nosocomial threat. Between December 2010 and April 2011, an increase of carbapenem-resistant A. baumannii infections occurred in several Marseille University Hospitals. The aim of this study was to investigate the increase of carbapenem-resistant A. baumannii infections and to characterize the mechanisms of carbapenem resistance. The increase was detected by a homemade computer surveillance program, known as EPIMIC, that monitors antibiotic resistance profiles on a weekly basis. During this period, positive samples of carbapenem-resistant A. baumannii were retrieved from patients hospitalized in different units. Genotyping of the isolates was performed using pulsed-field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST), and carbapenemase gene analyses were performed to detect the presence of carbapenemases and to determine the relationships of the isolates. Carbapenem-resistant A. baumannii were isolated in a total of 11 patients who were hospitalized in different hospitals units. We identified the presence of the bla(OXA23-like) carbapenemase-encoding gene in all of the isolates and found four major PFGE groups and different MLST groups. These results demonstrate a current evolution in the A. baumannii epidemiology in Marseille with a switch from an epidemic situation to an endemic situation and with several circulating clones.
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