@article{PAR00010117,
  title = {{I}nvestigation of {A}cinetobacter baumannii resistance to carbapenems in {M}arseille hospitals, south of {F}rance : a transition from an epidemic to an endemic situation},
  author = {{K}empf, {M}. and {R}olain, {J}. {M}. and {A}zza, {S}. and {D}iene, {S}. and {J}oly-{G}uillou, {M}. {L}. and {D}ubourg, {G}. and {C}olson, {P}. and {P}apazian, {L}. and {R}ichet, {H}. and {F}ournier, {P}. {E}. and {R}ibeiro, {A}. and {R}aoult, {D}idier},
  editor = {},
  language = {{ENG}},
  abstract = {{K}empf {M}, {R}olain {J}-{M}, {A}zza {S}, {D}iene {S}, {J}oly-{G}uillou {M}-{L}, {D}ubourg {G}, {C}olson {P}, {P}apazian {L}, {R}ichet {H}, {F}ournier {P}-{E}, {R}ibeiro {A}, {R}aoult {D}. {I}nvestigation of {A}cinetobacter baumannii resistance to carbapenems in {M}arseille hospitals, south of {F}rance: a transition from an epidemic to an endemic situation. {APMIS} 2013; 121: 64-71. {C}arbapenem-resistant {A}cinetobacter baumannii infections are a worldwide endemic nosocomial threat. {B}etween {D}ecember 2010 and {A}pril 2011, an increase of carbapenem-resistant {A}. baumannii infections occurred in several {M}arseille {U}niversity {H}ospitals. {T}he aim of this study was to investigate the increase of carbapenem-resistant {A}. baumannii infections and to characterize the mechanisms of carbapenem resistance. {T}he increase was detected by a homemade computer surveillance program, known as {EPIMIC}, that monitors antibiotic resistance profiles on a weekly basis. {D}uring this period, positive samples of carbapenem-resistant {A}. baumannii were retrieved from patients hospitalized in different units. {G}enotyping of the isolates was performed using pulsed-field gel electrophoresis ({PFGE}) and multi-locus sequence typing ({MLST}), and carbapenemase gene analyses were performed to detect the presence of carbapenemases and to determine the relationships of the isolates. {C}arbapenem-resistant {A}. baumannii were isolated in a total of 11 patients who were hospitalized in different hospitals units. {W}e identified the presence of the bla({OXA}23-like) carbapenemase-encoding gene in all of the isolates and found four major {PFGE} groups and different {MLST} groups. {T}hese results demonstrate a current evolution in the {A}. baumannii epidemiology in {M}arseille with a switch from an epidemic situation to an endemic situation and with several circulating clones.},
  keywords = {{A}cinetobacter baumannii ; multidrug resistant bacteria ; pulsed-field gel ; electrophoresis ; bla({OXA}23-like) ; endemic ; outbreak ; {FRANCE}},
  booktitle = {},
  journal = {{A}pmis},
  volume = {121},
  numero = {1},
  pages = {64--71},
  ISSN = {0903-4641},
  year = {2013},
  DOI = {10.1111/j.1600-0463.2012.02935.x},
  URL = {https://www.documentation.ird.fr/hor/{PAR}00010117},
}