Rolain J. M., Diene S. M., Kempf M., Gimenez G., Robert C., Raoult Didier. (2013). Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France. Antimicrobial Agents and Chemotherapy, 57 (1), p. 592-596. ISSN 0066-4804.
Titre du document
Real-time sequencing to decipher the molecular mechanism of resistance of a clinical pan-drug-resistant Acinetobacter baumannii isolate from Marseille, France
Rolain J. M., Diene S. M., Kempf M., Gimenez G., Robert C., Raoult Didier
Source
Antimicrobial Agents and Chemotherapy, 2013,
57 (1), p. 592-596 ISSN 0066-4804
We compare the whole-genome sequences of two multidrug-resistant clinical Acinetobacter baumannii isolates recovered in the same patient before (ABIsac_ColiS susceptible to colistin and rifampin only) and after (ABIsac_ColiR resistant to colistin and rifampin) treatment with colistin and rifampin. We decipher all the molecular mechanisms of antibiotic resistance, and we found mutations in the rpoB gene and in the PmrAB two-component system explaining resistance to rifampin and colistin in ABIsac_ColiR, respectively.
Plan de classement
Sciences fondamentales / Techniques d'analyse et de recherche [020]
;
Santé : généralités [050]
;
Biotechnologies [084]
