Logo IRD
Base Horizon

Publications des scientifiques de l'IRD

Notice PAR00004140

Cachet N., Hoakwie F., Bertani S., Bourdy Geneviève, Deharo Eric, Stien D., Houel E., Gornitzka H., Fillaux J., Chevalley Séverine, Valentin A., Jullian Valérie. Antimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae). Antimicrobial Agents and Chemotherapy, 2009, 53 (10), p. 4393-4398. ISSN 0066-4804

Lien direct chez l'éditeur doi:10.1128/aac.00951-09

TitreAntimalarial activity of simalikalactone E, a new quassinoid from Quassia amara L. (Simaroubaceae)
Année de publication2009
Type de documentArticle référencé dans le Web of Science : 000270020600047
AuteursCachet N., Hoakwie F., Bertani S., Bourdy Geneviève, Deharo Eric, Stien D., Houel E., Gornitzka H., Fillaux J., Chevalley Séverine, Valentin A., Jullian Valérie.
SourceAntimicrobial Agents and Chemotherapy, 2009, 53 (10), p. 4393-4398. ISSN 0066-4804
RésuméWe report the isolation and identification of a new quassinoid named simalikalactone E (SkE), extracted from a widely used Amazonian antimalarial remedy made out of Quassia amara L. (Simaroubaceae) leaves. This new molecule inhibited the growth of Plasmodium falciparum cultured in vitro by 50%, in the concentration range from 24 to 68 nM, independently of the strain sensitivity to chloroquine. We also showed that this compound was able to decrease gametocytemia with a 50% inhibitory concentration sevenfold lower than that of primaquine. SkE was found to be less toxic than simalikalactone D (SkD), another antimalarial quassinoid from Q. amara, and its cytotoxicity on mammalian cells was dependent on the cell line, displaying a good selectivity index when tested on nontumorogenic cells. In vivo, SkE inhibited murine malaria growth of Plasmodium vinckei petteri by 50% at 1 and 0.5 mg/kg of body weight/day, by the oral or intraperitoneal routes, respectively. The contribution of quassinoids as a source of antimalarial molecules needs therefore to be reconsidered.
LocalisationFonds IRD
Informations Contact
IRD - base Horizon / Pleins textes Mentions légales Flux RSS

Export des données

Le fonds documentaire IRD

72 000 publications des scientifiques de l'IRD, dont 40 000 accessibles en ligne.

Consultation du fonds IRD :

Autres centres de documentation :