New strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic results

New strain of Human T Lymphotropic Virus (HTLV) type 3 in a pygmy from Cameroon with peculiar HTLV serologic resultsCalattiniS.auteurautBetsemE.auteurautBassotS.auteurautChevalierS. A.auteurautMahieuxR.auteurautFromentAlainauteurautIRDGessainA.auteurauttextjournalArticleA search for human T lymphotropic virus (HTLV) types 1 and 2 and related viruses was performed by serological and molecular means on samples obtained from 421 adult villagers from the southern Cameroon forest areas. One individual (a 56-year-old Baka Pygmy hunter) was found to be HTLV-3 infected; however, there was a low proviral load in blood cells. Complete sequence analysis of this virus (HTLV-3(Lobak18)) indicated a close relationship to human HTLV-3(Pyl43) and simian STLV-3(CTO604) strains. Plasma samples from Lobak18, the HTLV-3 infected individual, exhibited a peculiar "HTLV-2-like" pattern on Western blot analysis and were serologically untypeable by line immunoassay. These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses.specialized052 journal of infectious diseases19945615642007http://www.documentation.ird.fr/hor/PAR0000358010.1086/596206IRD Bondyhttp://www.documentation.ird.fr/hor/PAR00003580IRD - Base Horizon / Pleins textes2009-07-082011-05-12PAR00003580fre